Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12890726 | 0.78 | PARP1 (0.60) | POLBPARP1 | |
| SCHEMBL662773 | 0.78 | PARP1 (0.60) | POLBPARP1 | |
| SCHEMBL666512 | 0.78 | PARP1 (0.60) | POLBPARP1 | |
| SCHEMBL15458224 | 0.72 | BCHE (0.48) | POLB | |
| SCHEMBL665549 | 0.72 | PARP1 (0.57) | POLBPARP1 | |
| SCHEMBL12890049 | 0.72 | PARP1 (0.57) | POLBPARP1 | |
| SCHEMBL663560 | 0.72 | PARP1 (0.57) | POLBPARP1 | |
| SCHEMBL663273 | 0.71 | POLB (0.52) | POLBPARP1 | |
| SCHEMBL664892 | 0.71 | PARP1 (0.58) | POLBPARP1 | |
| SCHEMBL2512532 | 0.70 | HTR2B (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2628481-B1 | Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV | ABBVIE BAHAMAS LTD (BS) | 2016-02-24 | — | — | EP | disclosed |