SCHEMBL17527271

SCHEMBL17527271

NC(=O)c1c(-c2ccc(Cl)c(Cl)c2)nn2c1CN(C(=O)NC1CC(F)C1)CC2

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CSNK1E P49674 20/20 0.62
CSNK1D P48730 11/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16711386 1.00 CSNK1E (0.62) CSNK1ECSNK1D
SCHEMBL16711312 1.00 CSNK1E (0.62) CSNK1ECSNK1D
SCHEMBL16711373 0.93 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL17527358 0.93 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL16711262 0.93 CSNK1E (0.63) CSNK1ECSNK1D
SCHEMBL16700161 0.91 CSNK1E (0.60) CSNK1ECSNK1D
SCHEMBL16699983 0.90 CSNK1E (0.59) CSNK1ECSNK1D
SCHEMBL16711260 0.89 CSNK1E (0.70) CSNK1ECSNK1D
SCHEMBL21131232 0.89 CSNK1E (0.70) CSNK1ECSNK1D
SCHEMBL16700481 0.89 CSNK1E (0.70) CSNK1ECSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9273058-B2 Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2016-03-01 US claimed
EP-3068785-B1 SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-06-26 EP disclosed