Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916333 | 0.92 | ALK (0.60) | ALKINSRLRRK2IGF1R | |
| SCHEMBL15206515 | 0.87 | ALK (0.63) | ALKINSRLRRK2IGF1R | |
| SCHEMBL17527454 | 0.83 | ALK (0.59) | ALKINSRLRRK2IGF1R | |
| SCHEMBL1493538 | 0.82 | ALK (0.60) | ALKINSRLRRK2 | |
| SCHEMBL17527320 | 0.76 | ALK (0.53) | ALKINSR | |
| SCHEMBL11901894 | 0.76 | ALK (0.59) | ALKINSRLRRK2IGF1R | |
| SCHEMBL1493649 | 0.75 | ALK (0.61) | ALKINSRLRRK2IGF1R | |
| SCHEMBL16752958 | 0.74 | ALK (1.00) | ALKINSRLRRK2 | |
| SCHEMBL16769540 | 0.73 | ALK (1.00) | ALK | |
| SCHEMBL1493535 | 0.73 | ALK (0.60) | ALKINSRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273077-B2 | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | claimed |