Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.54 |
| ▸ | TTK | P33981 | 5/20 | 0.54 |
| ▸ | GAK | O14976 | 3/20 | 0.54 |
| ▸ | INSR | P06213 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.54 |
| ▸ | LTK | P29376 | 3/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.54 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.54 |
| ▸ | INSRR | P14616 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CLK1 | P49759 | 2/20 | 0.54 |
| ▸ | FES | P07332 | 3/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | ROS1 | P08922 | 3/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17527458 | 0.94 | ALK (0.58) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL17527401 | 0.88 | ALK (0.54) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11916349 | 0.87 | ALK (0.54) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL17527459 | 0.83 | ALK (0.58) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11916350 | 0.82 | ALK (0.58) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11901912 | 0.80 | ALK (0.46) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11900490 | 0.80 | ALK (0.63) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11916340 | 0.79 | ALK (0.61) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL17527349 | 0.76 | ALK (0.47) | ALKTTKGAKINSRIGF1R | |
| SCHEMBL11901307 | 0.76 | ALK (0.52) | ALKTTKGAKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273077-B2 | Phosphorus derivatives as kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | claimed |