Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17527472 | 1.00 | BTK (0.52) | BTKPIK3CDKMT2AGFERPIK3CA | |
| SCHEMBL17545848 | 0.92 | BTK (0.63) | BTKPIK3CDPIK3CA | |
| SCHEMBL17527451 | 0.92 | BTK (0.49) | BTKPIK3CDKMT2AGFERPIK3R1 | |
| SCHEMBL17527452 | 0.92 | BTK (0.49) | BTKPIK3CDKMT2AGFERPIK3R1 | |
| SCHEMBL17545843 | 0.91 | BTK (0.64) | BTKPIK3CDKMT2APIK3CAPIK3R1 | |
| SCHEMBL18421256 | 0.90 | BTK (0.64) | BTK | |
| SCHEMBL17545831 | 0.90 | BTK (0.64) | BTK | |
| SCHEMBL17527477 | 0.89 | BTK (0.44) | BTKPIK3CDPIK3CAPIK3R1 | |
| SCHEMBL17527478 | 0.89 | BTK (0.44) | BTKPIK3CDPIK3CAPIK3R1 | |
| SCHEMBL17545834 | 0.88 | BTK (0.61) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |