Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.47 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.43 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746418 | 0.92 | PDE5A (0.41) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15519721 | 0.90 | PTGDR2 (0.39) | PDE5AGUCY1A1GUCY1B1PTGDR2 | |
| SCHEMBL19244701 | 0.89 | PTGDR2 (0.40) | PDE5AGUCY1A1GUCY1B1PTGDR2 | |
| SCHEMBL19244708 | 0.87 | PDE5A (0.36) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL19304767 | 0.86 | PDE5A (0.43) | PDE5AGUCY1A1GUCY1B1MEN1KMT2A | |
| SCHEMBL174635 | 0.85 | PDE5A (0.48) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15519699 | 0.85 | PDE5A (0.34) | PDE5AGUCY1A1GUCY1B1PTGDR2 | |
| SCHEMBL19244706 | 0.85 | GRIN1 (0.34) | PDE5AGUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL29219152 | 0.84 | PDE5A (0.47) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL18672347 | 0.84 | PDE5A (0.51) | PDE5AGUCY1A1GUCY1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751106-B1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER IP GMBH (DE) | 2017-10-18 | — | — | EP | disclosed |
| EP-2590987-B1 | CONDENSED 4-AMINOPYRIMIDINES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER IP GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |
| EP-2611802-B1 | BICYCLIC AZA-HETEROCYCLES AND THEIR USE | BAYER IP GMBH (DE) | 2016-02-24 | — | — | EP | disclosed |
| EP-2576547-B1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND USE THEREOF | ADVERIO PHARMA GMBH (DE) | 2016-01-27 | — | — | EP | disclosed |
| EP-2802592-A1 | SUBSTITUTED ANNULATED PYRIMIDINES AND TRIAZINES, AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2014-11-19 | — | — | EP | disclosed |
| EP-2708539-A1 | Annulated pyrimidines and triazines and their use | Bayer Intellectual Property GmbH (DE) | 2014-03-19 | — | — | EP | disclosed |
| EP-2687210-A1 | Stimulators and activators of soluble guanylate cyclase for use in the treatment of sickle cell anaemia and preservation of blood substitutes | Bayer Intellectual Property GmbH (DE) | 2014-01-22 | — | — | EP | disclosed |
| EP-2682394-A1 | 1H-pyrazolo[3,4-b]pyridin-triazine derivatives and their use for the treatment or the prevention of cardiovascular diseases | Bayer Intellectual Property GmbH (DE) | 2014-01-08 | — | — | EP | disclosed |
| WO-2013104703-A1 | SUBSTITUTED ANNULATED PYRIMIDINES AND TRIAZINES, AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-07-18 | — | — | WO | disclosed |
| EP-2611802-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| EP-2590979-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590987-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | Bayer Intellectual Property GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-2576547-A1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| WO-2012004258-A9 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012028647-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012004258-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004259-A1 | RING-FUSED 4 -AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
| WO-2011147809-A1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-12-01 | — | — | WO | disclosed |