Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rilematovir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rilematovir SCHEMBL29903269 | 1.00 | — | — | |
| Rilematovir SCHEMBL29413302 | 1.00 | — | — | |
| SCHEMBL16363561 | 0.90 | — | — | |
| SCHEMBL31069396 | 0.89 | — | — | |
| SCHEMBL31069350 | 0.88 | — | — | |
| SCHEMBL16374624 | 0.88 | — | — | |
| SCHEMBL23316225 | 0.88 | — | — | |
| SCHEMBL30703880 | 0.88 | — | — | |
| SCHEMBL28831275 | 0.88 | — | — | |
| SCHEMBL18056681 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051662-B1 | SYNTHESIS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2 YL}METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2024-02-07 | — | — | EP | claimed |
| EP-3720440-B1 | TREATMENT OF RSV WITH COMBINATION PRODUCT | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2023-05-24 | — | — | EP | claimed |
| CN-114630828-A | Synthesis of 3- ({ 5-chloro-1- [3- (methylsulfonyl) propyl ] -1H-indol-2-yl } methyl) -1- (2,2, 2-trifluoroethyl) -1, 3-dihydro-2H-imidazo [4,5-c ] pyridin-2-one | 杨森科学爱尔兰无限公司 | 2022-06-14 | — | — | CN | claimed |
| EP-3411028-B1 | COMBINATION PRODUCT FOR TREATING OR AMELIORATING RESPIRATORY SYNCYTIAL VIRUS INFECTION | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-05-05 | — | — | EP | claimed |
| CN-111491633-A | Treatment of RSV with a combination product | 爱尔兰詹森科学公司 | 2020-08-04 | — | — | CN | claimed |
| US-10363253-B2 | Combination products for the treatment of RSV | Janssen Sciences Ireland Unlimited Company (IE) | 2019-07-30 | — | — | US | claimed |
| US-12145933-B2 | Hemi (L)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethy)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one and pharmaceutical compositions comprising the same | Janssen Sciences Ireland Unlimited Company (IE) | 2024-11-19 | — | — | US | disclosed |
| US-20240158390-A1 | OTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV | JANSSEN SCIENCES IRELAND UNLMITED COMPANY (IE) | 2024-05-16 | — | — | US | disclosed |
| US-20240109894-A1 | SYNTHESIS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2-YL} METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2024-04-04 | — | — | US | disclosed |
| EP-4051662-B1 | SYNTHESIS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2 YL}METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2024-02-07 | — | — | EP | disclosed |
| WO-2023237732-A1 | RSV INHIBITING TRIAZOLO BEARING DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2023-12-14 | — | — | WO | disclosed |
| EP-3784667-B1 | HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2023-08-16 | — | — | EP | disclosed |
| US-11708369-B2 | Heteroaromatic compounds having activity against RSV | Janssen Sciences Ireland Unlimited Company (IE) | 2023-07-25 | — | — | US | disclosed |
| EP-3411028-A1 | COMBINATION PRODUCTS FOR THE TREATMENT OF RSV | Janssen Sciences Ireland UC (IE) | 2018-12-12 | — | — | EP | disclosed |
| EP-3288942-A1 | RSV ANTIVIRAL PYRAZOLO- AND TRIAZOLO-PYRIMIDINE COMPOUNDS | Janssen Sciences Ireland UC (IE) | 2018-03-07 | — | — | EP | disclosed |
| WO-2017134133-A1 | COMBINATION PRODUCTS FOR THE TREATMENT OF RSV | JANSSEN SCIENCES IRELAND UC (IE) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017134133-A1 | COMBINATION PRODUCTS FOR THE TREATMENT OF RSV | JANSSEN SCIENCES IRELAND UC (IE) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017134133-A1 | COMBINATION PRODUCTS FOR THE TREATMENT OF RSV | JANSSEN SCIENCES IRELAND UC (IE) | 2017-08-10 | — | — | WO | disclosed |
| WO-2016174079-A1 | RSV ANTIVIRAL PYRAZOLO- AND TRIAZOLO-PYRIMIDINE COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-11-03 | — | — | WO | disclosed |
| EP-2651922-B1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-02-24 | — | — | EP | disclosed |