Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 10/20 | 0.62 |
| ▸ | SKP2 | Q13309 | 10/20 | 0.62 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17538429 | 0.91 | CKS1B (0.60) | CKS1BSKP2TOP2A | |
| SCHEMBL21869714 | 0.79 | CKS1B (0.65) | CKS1BSKP2TOP2ACLK1DYRK1A | |
| SCHEMBL17506545 | 0.77 | CKS1B (1.00) | CKS1BSKP2CLK1IDH2 | |
| SCHEMBL21869737 | 0.75 | CKS1B (0.60) | CKS1BSKP2TOP2ACLK1DYRK1A | |
| SCHEMBL17506544 | 0.67 | CKS1B (1.00) | CKS1BSKP2CLK1 | |
| SCHEMBL21869662 | 0.66 | CKS1B (0.60) | CKS1BSKP2DYRK1ACYP11B1CYP11B2 | |
| SCHEMBL17538433 | 0.65 | CKS1B (0.60) | CKS1BSKP2 | |
| SCHEMBL21869671 | 0.65 | CKS1B (0.64) | CKS1BSKP2DYRK1ACYP11B1CYP11B2 | |
| SCHEMBL17506533 | 0.65 | CKS1B (1.00) | CKS1BSKP2 | |
| SCHEMBL10940225 | 0.65 | NPY5R (0.64) | NPY5RCYP11B1CYP11B2PIM1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025779-A1 | QUINOLINE DERIVATIVES USEFUL AS UBIQUITINATION INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |