Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.41 |
| ▸ | FGF2 | P09038 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539662 | 0.90 | FGFR1 (0.44) | FGFR1FGF2FGFR4FGFR3MET | |
| SCHEMBL17539599 | 0.88 | FGFR1 (0.36) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539394 | 0.79 | FGFR1 (0.41) | FGFR1FGF2FGFR4FGFR3GSK3B | |
| SCHEMBL17539334 | 0.79 | FGFR1 (0.60) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539426 | 0.79 | FGFR1 (0.58) | FGFR1FGF2FGFR4FGFR3KDR | |
| SCHEMBL17539634 | 0.78 | FGFR1 (0.60) | FGFR1 | |
| SCHEMBL17539495 | 0.77 | FGFR1 (0.40) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539536 | 0.77 | FGFR1 (0.40) | FGFR1FGF2FGFR4FGFR3 | |
| SCHEMBL17539667 | 0.77 | FGFR1 (0.61) | FGFR1 | |
| SCHEMBL17539552 | 0.77 | FGFR1 (0.59) | FGFR1FGF2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016027780-A1 | 4-AMINOPYRIDINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2016-02-25 | — | — | WO | disclosed |