Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.73 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.62 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17541227 | 0.90 | PDE5A (0.60) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL14754832 | 0.89 | PDE5A (0.73) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL17541304 | 0.89 | PDE5A (0.75) | PDE5A | |
| SCHEMBL17541328 | 0.88 | PDE5A (0.76) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL14746369 | 0.87 | PDE5A (0.79) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL19480642 | 0.86 | PDE5A (0.81) | PDE5A | |
| SCHEMBL17541229 | 0.86 | PDE5A (0.78) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL326432 | 0.86 | PDE5A (0.79) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913933 | 0.86 | PDE5A (0.82) | PDE5AGUCY1A1GUCY1B1 | |
| Acetic Acid SCHEMBL16267668 | 0.86 | PDE5A (0.93) | PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186251-A1 | SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016030362-A1 | SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-03 | — | — | WO | disclosed |