Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.70 |
| ▸ | JAK1 | P23458 | 19/20 | 0.70 |
| ▸ | JAK2 | O60674 | 18/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17512510 | 0.99 | TYK2 (0.69) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512666 | 0.94 | TYK2 (0.69) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL19649779 | 0.84 | TYK2 (0.62) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL17545396 | 0.83 | JAK2 (0.74) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512743 | 0.82 | JAK2 (0.73) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512683 | 0.82 | TYK2 (0.72) | TYK2JAK1JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL17512619 | 0.81 | TYK2 (0.72) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL18895862 | 0.80 | TYK2 (1.00) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL17512736 | 0.80 | TYK2 (1.00) | TYK2JAK1JAK2JAK3 | |
| SCHEMBL20408230 | 0.80 | TYK2 (1.00) | TYK2JAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11197867-B2 | Aminopyrimidinyl compounds | PFIZER INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20210377495-A1 | AMINOPYRIMIDINYL COMPOUNDS | PFIZER INC. (US) | 2021-12-02 | — | — | US | disclosed |
| US-10980815-B2 | Aminopyrimidinyl compounds | PFIZER INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200330477-A1 | AMINOPYRIMIDINYL COMPOUNDS | PFIZER INC. (US) | 2020-10-22 | — | — | US | disclosed |
| US-20200038409-A1 | AMINOPYRIMIDINYL COMPOUNDS | PFIZER INC. (US) | 2020-02-06 | — | — | US | disclosed |
| US-10463675-B2 | Aminopyrimidinyl compounds | PFIZER INC. (US) | 2019-11-05 | — | — | US | disclosed |
| EP-3183247-B9 | AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS | PFIZER (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-3183247-B1 | AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |
| US-20170239264-A1 | AMINOPYRIMIDINYL COMPOUNDS | PFIZER INC. (US) | 2017-08-24 | — | — | US | disclosed |
| US-9663526-B2 | Aminopyrimidinyl compounds | PFIZER INC. (US) | 2017-05-30 | — | — | US | disclosed |
| WO-2016027195-A1 | AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS | PFIZER INC. (US) | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.