Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740953 | 0.83 | GRM2 (0.45) | GRM2DNMT1NR1I2HSD11B1 | |
| SCHEMBL749544 | 0.80 | GRM2 (0.53) | GRM2 | |
| SCHEMBL21713512 | 0.79 | GRM2 (0.38) | GRM2DNMT1POLBNPC1ALDH1A1 | |
| SCHEMBL10819336 | 0.77 | GRM2 (0.42) | GRM2DNMT1NR1I2HSD11B1 | |
| Cyclopropane SCHEMBL750832 | 0.74 | GRM2 (0.51) | GRM2KCNH2 | |
| SCHEMBL1509228 | 0.70 | GRM2 (0.39) | GRM2POLBNPC1ALDH1A1MAPT | |
| SCHEMBL21713998 | 0.69 | SMN1; SMN2 (0.35) | GRM2POLBNPC1ALDH1A1HPGD | |
| SCHEMBL747854 | 0.68 | GRM2 (0.50) | GRM2 | |
| SCHEMBL13687332 | 0.68 | TP53 (0.45) | GRM2POLBNPC1ALDH1A1MAPT | |
| SCHEMBL21745150 | 0.67 | CA12 (0.41) | NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |