Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722385 | 0.91 | ALOX5AP (0.78) | ALOX5APCYP2C9CYP3A4PTGS1CYP2D6 | |
| SCHEMBL1722206 | 0.83 | ALOX5AP (0.82) | ALOX5APCYP2C9CYP3A4PTGS1 | |
| SCHEMBL176155 | 0.80 | ALOX5AP (0.84) | ALOX5APCYP2C9CYP3A4PTGS1CYP2D6 | |
| SCHEMBL176083 | 0.79 | ALOX5AP (0.82) | ALOX5APCYP2C9CYP3A4PTGS1CYP2D6 | |
| SCHEMBL1723339 | 0.79 | ALOX5AP (0.85) | ALOX5APCYP2C9CYP3A4PTGS1 | |
| SCHEMBL170170 | 0.78 | ALOX5AP (1.00) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL1723927 | 0.78 | ALOX5AP (0.89) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL175527 | 0.77 | ALOX5AP (0.82) | ALOX5APCYP2C9CYP3A4PTGS1 | |
| SCHEMBL176172 | 0.77 | ALOX5AP (0.89) | ALOX5APCYP2C9CYP3A4PTGS1CYP2D6 | |
| SCHEMBL170111 | 0.76 | ALOX5AP (0.70) | ALOX5APCYP2C9CYP3A4PTGS1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943219-B8 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | PANMIRA PHARMACEUTICALS LLC (US) | 2012-03-07 | — | — | EP | claimed |
| JP-4705986-B2 | — | — | 2011-06-22 | — | — | JP | claimed |