SCHEMBL17552011

SCHEMBL17552011

O=C(c1ccccc1)c1cc(-c2ccncc2)c(-c2ccc(F)cc2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 18/20 1.00
LTA4H P09960 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5253265 0.85 MAPK14 (1.00) MAPK14
SCHEMBL17542551 0.82 MAPK14 (1.00) MAPK14
SCHEMBL17552010 0.81 MAPK14 (1.00) MAPK14
SCHEMBL17542503 0.77 MAPK14 (1.00) MAPK14
SCHEMBL8985342 0.76 MAPK14 (0.83) MAPK14
SCHEMBL19349035 0.76 MAPK14 (0.78) MAPK14
SCHEMBL5250495 0.76 MAPK14 (1.00) MAPK14
SCHEMBL19367813 0.75 MAPK14 (0.80) MAPK14
SCHEMBL19367820 0.75 MAPK14 (0.83) MAPK14
SCHEMBL13309308 0.74 MAPK14 (0.59) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3186245-B1 MAPK INHIBITORS EverBrilliant Pharma Pty Ltd (AU) 2021-06-23 EP disclosed
EP-3186245-B1 MAPK INHIBITORS EverBrilliant Pharma Pty Ltd (AU) 2021-06-23 EP disclosed
US-20170266173-A1 MAPK INHIBITORS EVERBRILLIANT PHARMA PTY LTD. (AU) 2017-09-21 US disclosed
US-20170266173-A1 MAPK INHIBITORS EVERBRILLIANT PHARMA PTY LTD. (AU) 2017-09-21 US disclosed
US-20170266173-A1 MAPK INHIBITORS EVERBRILLIANT PHARMA PTY LTD. (AU) 2017-09-21 US disclosed
WO-2016029263-A1 MAPK INHIBITORS WANG BING HUI (AU) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170266173-A1 MAPK INHIBITORS MAPK1, MAPK4, MAPK3 MAPK14 13/4885LTA4H 1617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.