Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.42 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068276 | 0.84 | MTOR (0.62) | MTORPIK3CAADORA3ADORA2BRICTOR | |
| SCHEMBL481737 | 0.84 | MTOR (0.79) | MTORPIK3CA | |
| SCHEMBL481556 | 0.80 | MTOR (0.48) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481727 | 0.79 | MTOR (0.69) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481513 | 0.78 | MTOR (0.75) | MTORPIK3CA | |
| SCHEMBL481806 | 0.77 | FYN (0.61) | MTORPIK3CA | |
| SCHEMBL481901 | 0.77 | FYN (0.61) | MTORPIK3CA | |
| SCHEMBL481805 | 0.77 | FYN (0.61) | MTORPIK3CA | |
| SCHEMBL482273 | 0.76 | MTOR (0.44) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL28068202 | 0.75 | MTOR (0.51) | MTORADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2992878-A1 | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2016-03-09 | — | — | EP | disclosed |