Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668640 | 0.82 | PTK2 (0.47) | KDM4EMEN1MAPTKMT2AJAK2 | |
| SCHEMBL670106 | 0.79 | PTK2 (0.51) | KDM4EMEN1MAPTKMT2AMAPK8 | |
| SCHEMBL17554668 | 0.75 | PTK2 (0.54) | MAPK9MAPK10JAK2JAK3FLT3 | |
| SCHEMBL671026 | 0.70 | PTK2 (0.50) | JAK2JAK3 | |
| SCHEMBL669740 | 0.68 | JAK2 (0.49) | JAK2JAK3 | |
| SCHEMBL10125265 | 0.67 | PTK2 (0.41) | JAK2JAK3FFAR1FFAR4 | |
| SCHEMBL670088 | 0.67 | PTK2 (0.44) | JAK2JAK3 | |
| SCHEMBL17571817 | 0.66 | RXFP1 (0.41) | MEN1KMT2AGAAJAK2JAK3 | |
| SCHEMBL10125285 | 0.66 | PTK2 (0.42) | JAK2JAK3EGFR | |
| SCHEMBL4375340 | 0.64 | JAK2 (0.68) | MAPK8PIP4K2CJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | claimed |