SCHEMBL1755548

SCHEMBL1755548

Cc1ccc(C(C)(c2ccc(Oc3ccc4c(c3)C(=O)N(C)C4=O)cc2)c2ccc(Oc3ccc4c(c3)C(=O)N(c3cccc(C)c3)C4=O)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 0.47
KMT2A Q03164 8/20 0.47
ALDH1A1 P00352 6/20 0.47
MAPK1 P28482 2/20 0.47
POLB P06746 1/20 0.47
GAA P10253 2/20 0.46
BRD4 O60885 1/20 0.46
MAPT P10636 2/20 0.44
PKM P14618 1/20 0.42
LPAR1 Q92633 2/20 0.42
LPAR3 Q9UBY5 2/20 0.42
LPAR5 Q9H1C0 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MCHR1 Q99705 1/20 0.41
USP2 O75604 1/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
HTT P42858 3/20 0.41
HPGD P15428 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL678816 0.92 MEN1 (0.47) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL1755562 0.91 MEN1 (0.42) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL25627495 0.88 BRD4 (0.50) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL12532602 0.88 MEN1 (0.44) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL26030942 0.88 MEN1 (0.51) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL29339126 0.88 MEN1 (0.51) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL14010053 0.87 BRD4 (0.58) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL13899508 0.87 MEN1 (0.59) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL12201312 0.87 BRD4 (0.48) MEN1KMT2AALDH1A1MAPK1POLB
SCHEMBL19033430 0.87 MEN1 (0.43) MEN1KMT2AALDH1A1MAPK1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2441789-A2 Electronic devices containing polyetherimide components General Electric Company (US) 2012-04-18 EP disclosed