Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898325 | 0.90 | ALK (0.79) | ALKCYP2D6HRH3 | |
| SCHEMBL897509 | 0.88 | ALK (0.61) | ALK | |
| SCHEMBL24675625 | 0.87 | ALK (0.59) | ALKCYP2D6HRH3 | |
| SCHEMBL1755742 | 0.86 | ALK (0.62) | ALK | |
| SCHEMBL7809260 | 0.84 | ALK (0.64) | ALK | |
| SCHEMBL7810026 | 0.81 | ALK (0.65) | ALK | |
| SCHEMBL20366614 | 0.79 | ALK (0.80) | ALK | |
| SCHEMBL897399 | 0.78 | ALK (1.00) | ALK | |
| SCHEMBL17434686 | 0.78 | ALK (0.89) | ALK | |
| SCHEMBL20004584 | 0.77 | ALK (0.62) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |