Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170325 | 0.92 | ALOX5AP (0.78) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL174773 | 0.87 | ALOX5AP (0.69) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL4191928 | 0.82 | ALOX5AP (0.78) | ALOX5APPTGS1 | |
| SCHEMBL170125 | 0.81 | ALOX5AP (0.78) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL167693 | 0.81 | ALOX5AP (0.78) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL175479 | 0.80 | ALOX5AP (0.82) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL170022 | 0.80 | ALOX5AP (0.89) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL1885191 | 0.80 | ALOX5AP (0.81) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 | |
| SCHEMBL167794 | 0.79 | ALOX5AP (1.00) | ALOX5APCYP3A4CYP2C9ALOX5PTGS1 | |
| SCHEMBL169592 | 0.79 | ALOX5AP (0.81) | ALOX5APCYP3A4CYP2C9ALOX5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943219-B8 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | PANMIRA PHARMACEUTICALS LLC (US) | 2012-03-07 | — | — | EP | disclosed |