Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897781 | 0.86 | ALK (0.71) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL1755924 | 0.83 | ALK (0.79) | ALKKDR | |
| SCHEMBL7809756 | 0.82 | ALK (0.49) | ALKKDR | |
| SCHEMBL30009797 | 0.82 | ALK (0.54) | ALKSRPK2SRPK1 | |
| SCHEMBL1755956 | 0.82 | ALK (0.57) | ALKKDRKIT | |
| SCHEMBL1755889 | 0.81 | ALK (0.49) | ALKSRPK2SRPK1 | |
| SCHEMBL7800677 | 0.78 | ALK (0.55) | ALK | |
| SCHEMBL7807321 | 0.77 | ALK (0.73) | ALKKDRKIT | |
| SCHEMBL20004194 | 0.77 | SRPK1 (0.60) | ALKKDRSRPK2SRPK1 | |
| SCHEMBL7805855 | 0.77 | ALK (0.78) | ALKKDRKITSRPK2SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |