Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755885 | 0.97 | ALK (0.69) | ALKKDRKIT | |
| SCHEMBL7812954 | 0.93 | ALK (0.69) | ALKKDRKIT | |
| SCHEMBL7806738 | 0.92 | ALK (0.74) | ALKKDRKIT | |
| SCHEMBL1755904 | 0.91 | ALK (0.68) | ALKKDRKIT | |
| SCHEMBL1755981 | 0.90 | ALK (0.81) | ALKKDRKIT | |
| SCHEMBL896822 | 0.89 | ALK (0.80) | ALKKDRKIT | |
| SCHEMBL7809513 | 0.88 | ALK (0.80) | ALKKDRKIT | |
| SCHEMBL7806292 | 0.87 | ALK (0.72) | ALKKDRKIT | |
| SCHEMBL7819599 | 0.87 | ALK (0.64) | ALKKDRKIT | |
| SCHEMBL7811955 | 0.87 | ALK (0.70) | ALKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |