Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17558421 | 1.00 | IGF1R (0.41) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6175170 | 0.95 | IGF1R (0.44) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6173328 | 0.86 | IGF1R (0.44) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6175255 | 0.86 | IGF1R (0.44) | IGF1RNAMPTARKMT2ACYP2C9 | |
| Trifluoroacetic Acid SCHEMBL17558354 | 0.86 | AR (0.40) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6171403 | 0.85 | IGF1R (0.43) | IGF1RNAMPTARKMT2ACYP2C9 | |
| Trifluoroacetic Acid SCHEMBL17558453 | 0.84 | IGF1R (0.44) | IGF1RARCYP2C9CYP3A4GAA | |
| SCHEMBL6174655 | 0.84 | IGF1R (0.39) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6171133 | 0.84 | IGF1R (0.40) | IGF1RNAMPTARKMT2ACYP2C9 | |
| SCHEMBL6175293 | 0.84 | IGF1R (0.45) | IGF1RNAMPTARKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |