Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943071 | 0.87 | IGF1R (0.80) | IGF1R | |
| SCHEMBL2939981 | 0.84 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4851290 | 0.83 | IGF1R (0.76) | IGF1R | |
| SCHEMBL2941768 | 0.83 | IGF1R (0.73) | IGF1R | |
| SCHEMBL1130587 | 0.81 | IGF1R (1.00) | IGF1R | |
| SCHEMBL2941767 | 0.80 | IGF1R (0.76) | IGF1R | |
| SCHEMBL13039126 | 0.79 | IGF1R (0.72) | IGF1R | |
| SCHEMBL2991808 | 0.78 | IGF1R (0.75) | IGF1R | |
| SCHEMBL3728553 | 0.78 | IGF1R (0.63) | IGF1R | |
| SCHEMBL2941196 | 0.77 | IGF1R (0.81) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |