Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.51 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.45 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.45 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812909 | 0.89 | ALK (0.51) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL7812737 | 0.85 | ALK (0.55) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL1755874 | 0.85 | ALK (0.59) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL1755802 | 0.83 | ALK (0.58) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL7809636 | 0.83 | ALK (0.61) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL7805433 | 0.81 | ALK (0.75) | ALKKDRKIT | |
| SCHEMBL1755811 | 0.81 | ALK (0.75) | ALKKDRKIT | |
| SCHEMBL7806976 | 0.77 | ALK (0.54) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL897025 | 0.76 | ALK (0.77) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL7805522 | 0.76 | ALK (0.59) | ALKSRPK2SRPK1EML4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |