Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | KIT | P10721 | 2/20 | 0.65 |
| ▸ | SRPK2 | P78362 | 2/20 | 0.64 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.64 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | ROS1 | P08922 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.64 |
| ▸ | FER | P16591 | 1/20 | 0.64 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897924 | 0.89 | ALK (0.76) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL897633 | 0.85 | ALK (0.85) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL897496 | 0.85 | ALK (0.79) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL897984 | 0.85 | ALK (0.78) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL898225 | 0.85 | ALK (0.85) | ALKKDRSRPK2SRPK1EML4 | |
| SCHEMBL29962217 | 0.85 | ALK (0.85) | ALKKDRSRPK2SRPK1EML4 | |
| SCHEMBL897753 | 0.84 | ALK (0.78) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL897286 | 0.84 | ALK (1.00) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL897033 | 0.83 | ALK (1.00) | ALKKDRKITSRPK2SRPK1 | |
| SCHEMBL898111 | 0.83 | ALK (0.75) | ALKKDRKITSRPK2SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |