Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.38 |
| ▸ | RET | P07949 | 6/20 | 0.35 |
| ▸ | ROS1 | P08922 | 6/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.35 |
| ▸ | GAK | O14976 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.35 |
| ▸ | FER | P16591 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.35 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10246563 | 0.88 | ALK (0.46) | ALKRETROS1EML4GAK | |
| Iodide SCHEMBL898117 | 0.88 | ALK (0.46) | ALKRETROS1EML4GAK | |
| Iodide SCHEMBL29962380 | 0.88 | ALK (0.46) | ALKRETROS1EML4GAK | |
| SCHEMBL898491 | 0.80 | ALK (0.45) | ALKRETROS1EML4GAK | |
| SCHEMBL17448484 | 0.77 | ALK (0.42) | ALKRETROS1EML4GAK | |
| SCHEMBL20004313 | 0.76 | ALK (0.44) | ALKRETROS1EML4GAK | |
| SCHEMBL897613 | 0.76 | ALK (0.42) | ALKRETROS1EML4GAK | |
| SCHEMBL29940254 | 0.75 | ALK (0.43) | ALKRETROS1EML4GAK | |
| SCHEMBL898642 | 0.75 | ALK (0.43) | ALKRETROS1EML4GAK | |
| SCHEMBL29940372 | 0.75 | ALK (0.43) | ALKRETROS1EML4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |