Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | WEE1 | P30291 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897191 | 0.85 | ALK (0.69) | ALKKITKDR | |
| SCHEMBL7813868 | 0.85 | ALK (0.59) | ALK | |
| SCHEMBL7813874 | 0.81 | ALK (0.79) | ALK | |
| SCHEMBL7802173 | 0.80 | ALK (0.66) | ALK | |
| SCHEMBL1755913 | 0.80 | ALK (0.52) | ALK | |
| SCHEMBL7813823 | 0.78 | ALK (0.78) | ALKKDR | |
| SCHEMBL1756006 | 0.77 | ALK (0.72) | ALK | |
| SCHEMBL7807148 | 0.77 | ALK (0.61) | ALKKDR | |
| SCHEMBL1755940 | 0.75 | ALK (0.64) | ALKKITKDR | |
| SCHEMBL7815431 | 0.75 | ALK (0.53) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |