Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898678 | 0.83 | ALK (0.63) | ALKNTRK1PRKCAGSK3B | |
| SCHEMBL29962504 | 0.83 | ALK (0.63) | ALKNTRK1PRKCAGSK3B | |
| SCHEMBL29962810 | 0.81 | ALK (0.61) | ALKNTRK1 | |
| SCHEMBL29962768 | 0.81 | ALK (0.71) | ALKNTRK1 | |
| SCHEMBL898329 | 0.81 | ALK (0.61) | ALKNTRK1 | |
| SCHEMBL898276 | 0.81 | ALK (0.71) | ALKNTRK1 | |
| SCHEMBL29962463 | 0.74 | NTRK1 (0.53) | ALKNTRK1PRKCAGSK3B | |
| SCHEMBL898401 | 0.74 | NTRK1 (0.53) | ALKNTRK1PRKCAGSK3B | |
| SCHEMBL7810026 | 0.72 | ALK (0.65) | ALK | |
| SCHEMBL898402 | 0.72 | ALK (0.66) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |