Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17561742 | 0.94 | ABL1 (0.87) | ABL1KCNH2 | |
| SCHEMBL17561743 | 0.94 | ABL1 (0.87) | ABL1KCNH2 | |
| SCHEMBL17561750 | 0.94 | ABL1 (0.87) | ABL1KCNH2 | |
| SCHEMBL17561861 | 0.93 | ABL1 (0.88) | ABL1KCNH2 | |
| SCHEMBL15391754 | 0.93 | ABL1 (0.89) | ABL1KCNH2 | |
| SCHEMBL17561864 | 0.92 | ABL1 (0.81) | ABL1KCNH2 | |
| SCHEMBL17561885 | 0.92 | ABL1 (0.88) | ABL1 | |
| SCHEMBL17561886 | 0.92 | ABL1 (0.88) | ABL1 | |
| SCHEMBL17561857 | 0.92 | ABL1 (0.82) | ABL1 | |
| SCHEMBL17561856 | 0.91 | ABL1 (0.85) | ABL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278981-B2 | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 | NOVARTIS AG (CH) | 2016-03-08 | — | — | US | disclosed |