Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.87 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17561931 | 0.95 | ABL1 (0.88) | ABL1OPRM1KCNH2 | |
| SCHEMBL16860311 | 0.93 | ABL1 (1.00) | ABL1OPRM1KCNH2 | |
| SCHEMBL16860434 | 0.92 | ABL1 (0.88) | ABL1OPRM1KCNH2 | |
| SCHEMBL16860316 | 0.92 | ABL1 (1.00) | ABL1OPRM1KCNH2 | |
| SCHEMBL17561918 | 0.91 | ABL1 (0.77) | ABL1 | |
| SCHEMBL17561917 | 0.90 | ABL1 (0.87) | ABL1 | |
| SCHEMBL17561916 | 0.89 | ABL1 (0.84) | ABL1 | |
| SCHEMBL17561920 | 0.87 | ABL1 (0.84) | ABL1 | |
| SCHEMBL17561934 | 0.86 | ABL1 (0.74) | ABL1 | |
| SCHEMBL17561936 | 0.84 | ABL1 (0.87) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858988-B1 | BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-9278981-B2 | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 | NOVARTIS AG (CH) | 2016-03-08 | — | — | US | disclosed |