Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8266561 | 0.86 | BACE1 (0.60) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL10120746 | 0.83 | BACE1 (0.65) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL7518108 | 0.81 | BACE1 (0.62) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL10120979 | 0.81 | BACE1 (0.62) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL7584937 | 0.78 | BACE1 (0.60) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL7518412 | 0.77 | BACE1 (0.65) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL7512580 | 0.77 | BACE1 (0.65) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL13407706 | 0.76 | BACE1 (0.61) | BACE1LMNAHTTMEN1ALDH1A1 | |
| SCHEMBL17570159 | 0.74 | BACE1 (0.55) | BACE1LMNAHTT | |
| SCHEMBL12410201 | 0.73 | BACE1 (0.53) | BACE1LMNAHTTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2153832-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |