Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10117371 | 0.82 | TDP1 (0.50) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL21470915 | 0.80 | TDP1 (0.48) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL13876981 | 0.80 | TDP1 (0.48) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL12085923 | 0.78 | TDP1 (0.56) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL18272943 | 0.78 | TDP1 (0.47) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL18155881 | 0.78 | TDP1 (0.47) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL3341020 | 0.78 | TDP1 (0.67) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL11989021 | 0.78 | TDP1 (0.55) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL16923544 | 0.77 | TDP1 (0.55) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL12237932 | 0.77 | TDP1 (0.46) | TDP1MEN1GAAKMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016034946-A2 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-03-10 | — | — | WO | disclosed |