Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591058 | 0.89 | POLB (0.51) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL1591053 | 0.80 | KDM4E (0.51) | TSHRRAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL13047128 | 0.80 | POLB (0.56) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL13047256 | 0.79 | TP53 (0.62) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL1590410 | 0.79 | TP53 (0.56) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL13047191 | 0.78 | TSHR (0.58) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL13046896 | 0.78 | POLB (0.59) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL13047022 | 0.77 | POLB (0.56) | POLBTP53THRBTSHRRAB9A | |
| SCHEMBL17577791 | 0.77 | KMT2A (0.44) | POLBTP53TSHRRAB9AKMT2A | |
| SCHEMBL13046820 | 0.76 | POLB (0.51) | POLBTP53THRBTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-03-09 | — | — | EP | disclosed |