Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.49 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17584062 | 1.00 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1HSP90B1TRAP1ROCK2 | |
| SCHEMBL17584069 | 0.92 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL17583998 | 0.89 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL17583994 | 0.89 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL17583993 | 0.87 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL17583991 | 0.87 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3633250 | 0.86 | HSP90AB1 (0.67) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL8141246 | 0.86 | HSP90AB1 (0.67) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL17584025 | 0.85 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1TRAP1ROCK2 | |
| SCHEMBL17584024 | 0.85 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1TRAP1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190225587-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | ESANEX, INC. | 2019-07-25 | — | — | US | claimed |
| US-10246421-B2 | Indazolyl- and indolyl-benzamide derivatives | ESANEX, INC. (US) | 2019-04-02 | — | — | US | claimed |
| US-20160075662-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | ESANEX, INC. | 2016-03-17 | — | — | US | claimed |
| US-10246421-B2 | Indazolyl- and indolyl-benzamide derivatives | ESANEX, INC. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20160075662-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | ESANEX, INC. | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246421-B2 | Indazolyl- and indolyl-benzamide derivatives | IDO2, MKI67, IDO1 | HSP90AA1 682/4885HSP90AB1 361/4885HSP90B1 1479/4885 |
| US-20190225587-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | IDO2, MKI67, IDO1 | HSP90AA1 682/4885HSP90AB1 361/4885HSP90B1 1479/4885 |
| US-20160075662-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | IDO2, MKI67, IDO1 | HSP90AA1 682/4885HSP90AB1 361/4885HSP90B1 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.