Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 8/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 5/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17586160 | 0.85 | IP6K1 (0.47) | IP6K1IP6K3IP6K2PARP1APAF1 | |
| SCHEMBL17586158 | 0.85 | IP6K1 (0.49) | IP6K1IP6K3IP6K2PARP1APAF1 | |
| SCHEMBL17586151 | 0.82 | IP6K1 (0.46) | IP6K1IP6K3IP6K2PARP1CHEK1 | |
| SCHEMBL17586159 | 0.82 | IP6K1 (0.46) | IP6K1IP6K3IP6K2PARP1POLB | |
| SCHEMBL17586178 | 0.81 | IP6K1 (0.43) | IP6K1IP6K3IP6K2PARP1APAF1 | |
| SCHEMBL17586155 | 0.80 | IP6K1 (0.45) | IP6K1IP6K3IP6K2PARP1APAF1 | |
| SCHEMBL17586171 | 0.79 | IP6K1 (0.44) | IP6K1IP6K3IP6K2PARP1POLB | |
| SCHEMBL17586176 | 0.79 | IP6K1 (0.42) | IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL17586185 | 0.78 | IP6K1 (0.52) | IP6K1IP6K3IP6K2PARP1KDM4C | |
| SCHEMBL17586172 | 0.78 | KDM4C (0.38) | IP6K1IP6K3IP6K2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493426-B2 | Quinazolinone derivatives useful as FGFR kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | FGFR1, FGFR3, FGFR2 | IP6K1 471/4885IP6K3 443/4885IP6K2 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.