Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 19/20 | 0.87 |
| ▸ | KDR | P35968 | 3/20 | 0.80 |
| ▸ | CSF1R | P07333 | 2/20 | 0.80 |
| ▸ | RET | P07949 | 2/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.80 |
| ▸ | KIT | P10721 | 2/20 | 0.80 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.80 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.80 |
| ▸ | MUSK | O15146 | 1/20 | 0.80 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.80 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | PAK3 | O75914 | 1/20 | 0.80 |
| ▸ | STK10 | O94804 | 1/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 1/20 | 0.80 |
| ▸ | YES1 | P07947 | 1/20 | 0.80 |
| ▸ | LYN | P07948 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759297 | 0.95 | FLT3 (0.88) | FLT3KDRCSF1RRETPDGFRB | |
| SCHEMBL72924 | 0.93 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB | |
| Hydrochloric Acid SCHEMBL742748 | 0.93 | FLT3 (0.99) | FLT3KDRCSF1RRETPDGFRB | |
| Hydrochloric Acid SCHEMBL74122 | 0.93 | FLT3 (0.99) | FLT3KDRCSF1RRETPDGFRB | |
| SCHEMBL1759073 | 0.92 | FLT3 (0.87) | FLT3KDRCSF1RRETPDGFRB | |
| Quizartinib SCHEMBL72923 | 0.89 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB | |
| Quizartinib SCHEMBL29349937 | 0.89 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB | |
| Quizartinib SCHEMBL74121 | 0.88 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB | |
| Quizartinib SCHEMBL742377 | 0.88 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB | |
| Quizartinib SCHEMBL29435035 | 0.88 | FLT3 (1.00) | FLT3KDRCSF1RRETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056764-A1 | ISOTOPICALLY ENRICHED OR FLUORINATED IMIDAZO[2,1-B][1,3]BENZOTHIAZOLES | AMBIT BIOSCIENCES CORP. (US) | 2011-05-12 | — | — | WO | disclosed |