Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27180909 | 0.81 | MEN1 (1.00) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL30926981 | 0.81 | MEN1 (1.00) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL14372362 | 0.78 | CA1 (0.77) | KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL27181470 | 0.78 | MEN1 (0.73) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL30926520 | 0.78 | MEN1 (0.66) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL27179949 | 0.78 | MEN1 (0.66) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL13453572 | 0.78 | MEN1 (0.80) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL27181129 | 0.78 | MEN1 (0.70) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL30926725 | 0.76 | MAPT (0.63) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL30926458 | 0.76 | GRM4 (0.74) | KMT2AMAPTMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |