Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.55 |
| ▸ | BRD2 | P25440 | 12/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 12/20 | 0.55 |
| ▸ | EP300 | Q09472 | 2/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TAF1 | P21675 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.50 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | CCL2 | P13500 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17594557 | 0.99 | BRD4 (0.54) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL19472546 | 0.89 | BRD4 (0.58) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL15890971 | 0.85 | BRD4 (0.54) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL15890930 | 0.85 | BRD4 (0.54) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL1872084 | 0.82 | BRD4 (0.56) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL1872086 | 0.82 | BRD4 (0.56) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL30574301 | 0.82 | BRD4 (0.56) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL1872082 | 0.82 | BRD4 (0.56) | BRD4BRD2BRD3EP300BRDT | |
| SCHEMBL26131894 | 0.82 | BRD4 (0.56) | BRD4BRD2BRD3 | |
| SCHEMBL1906902 | 0.82 | BRD4 (0.59) | BRD4BRD2BRD3EP300BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191476-B1 | TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-10-24 | — | — | EP | disclosed |
| US-10059699-B2 | Tetrahydroquinoline derivatives as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-08-28 | — | — | US | disclosed |
| US-20170298047-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-19 | — | — | US | disclosed |
| EP-3191476-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property Limited (GB) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038120-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298047-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRDT, BRD3 | BRD4 1/4885BRD2 4/4885BRD3 3/4885 |
| US-10059699-B2 | Tetrahydroquinoline derivatives as bromodomain inhibitors | BRD4, BRDT, BRD3 | BRD4 1/4885BRD2 4/4885BRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.