Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PDE8B | O95263 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11653025 | 0.87 | PDE10A (0.53) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL28920469 | 0.81 | PDE10A (0.56) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL17376488 | 0.80 | PDE10A (0.47) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL4427265 | 0.79 | PDE10A (0.65) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL6033787 | 0.76 | PDE10A (1.00) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL4420332 | 0.75 | PDE10A (0.60) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL275864 | 0.75 | PDE10A (1.00) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL10406959 | 0.71 | PDE10A (0.47) | PDE10APDE4APDE8B | |
| SCHEMBL7193572 | 0.70 | PDE10A (0.45) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL1706456 | 0.70 | PDE10A (0.54) | PDE10ACHRM3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| US-4323570-A | HYPOTENSIVE AGENTS AND TREATING GLAUCOMA | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-04-06 | — | — | US | disclosed |