Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15008597 | 0.82 | EZH2 (0.52) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL7392417 | 0.75 | TP53 (0.66) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL377833 | 0.75 | SIRT2 (0.56) | KDM4ETP53 | |
| SCHEMBL8504043 | 0.74 | KMT2A (0.76) | KMT2AMEN1L3MBTL1POLBEZH2 | |
| Hydrochloric Acid SCHEMBL7385416 | 0.74 | TP53 (0.64) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4535105 | 0.73 | HSP90AA1 (0.55) | TP53 | |
| SCHEMBL4611752 | 0.73 | KMT2A (0.45) | KMT2AMEN1ALOX15L3MBTL1POLB | |
| SCHEMBL29470849 | 0.73 | HSP90AA1 (0.55) | TP53 | |
| SCHEMBL22605677 | 0.72 | JAK2 (0.50) | ALDH1A1KDM4ETP53 | |
| SCHEMBL27538853 | 0.72 | RPS6KB1 (0.56) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191473-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | Esanex, Inc. (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016040809-A1 | INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES | ESANEX, INC. (US) | 2016-03-17 | — | — | WO | disclosed |