Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 9/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135313 | 0.92 | CETP (0.39) | CETPPDK2GPBAR1 | |
| SCHEMBL130695 | 0.86 | CETP (0.41) | CETPPDK2GPBAR1 | |
| SCHEMBL132303 | 0.85 | CETP (0.40) | CETPPDK2GPBAR1 | |
| SCHEMBL131743 | 0.81 | CETP (0.44) | CETPPDK2GPBAR1 | |
| SCHEMBL134654 | 0.81 | CETP (0.42) | CETPPDK2 | |
| SCHEMBL1588147 | 0.80 | CETP (0.41) | CETPPDK2GPBAR1 | |
| SCHEMBL131317 | 0.80 | CETP (0.40) | CETPPDK2 | |
| SCHEMBL1587427 | 0.79 | CETP (0.41) | CETPPDK2GPBAR1 | |
| SCHEMBL1588012 | 0.79 | CETP (0.41) | CETPPDK2 | |
| SCHEMBL5071423 | 0.79 | CETP (0.44) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979331-B1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-07 | — | — | EP | disclosed |