Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.81 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.81 |
| ▸ | MTOR | P42345 | 6/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113893 | 0.89 | PIK3CA (0.84) | PIK3CAPIK3R1MTOR | |
| SCHEMBL166649 | 0.87 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL176057 | 0.86 | PIK3CA (0.77) | PIK3CAPIK3R1MTOR | |
| SCHEMBL167280 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL167706 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL115701 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL166736 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR | |
| SCHEMBL3116122 | 0.83 | PIK3CA (0.81) | PIK3CAPIK3R1MTOR | |
| SCHEMBL169385 | 0.83 | PIK3CA (0.80) | PIK3CAPIK3R1MTOR | |
| SCHEMBL116214 | 0.83 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |