Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604699 | 0.94 | CYP2C19 (0.49) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17606256 | 0.82 | CYP2C19 (0.49) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17606326 | 0.81 | CYP2C19 (0.66) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17605480 | 0.80 | POLB (0.63) | KMT2APOLBMEN1MAPTLMNA | |
| SCHEMBL17605478 | 0.80 | POLB (0.63) | KMT2APOLBMEN1MAPTLMNA | |
| SCHEMBL17605083 | 0.79 | EP300 (0.57) | CYP2C19KMT2AMEN1MAPTLMNA | |
| SCHEMBL17605268 | 0.79 | KMT2A (0.41) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17605103 | 0.78 | KMT2A (0.53) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17606568 | 0.77 | CYP2C19 (0.44) | CYP2C19KMT2APOLBMEN1MAPT | |
| SCHEMBL17606065 | 0.77 | TSHR (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044770-A1 | SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE | ABBVIE INC. (US) | 2016-03-24 | — | — | WO | disclosed |