SCHEMBL1760756

SCHEMBL1760756

C[n+]1ccn(CCCN2C(=O)c3cccc4c(NCCO)ccc(c34)C2=O)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK3 O43781 1/20 0.58
RPS6KB1 P23443 1/20 0.58
EPHA2 P29317 1/20 0.58
FLT4 P35916 1/20 0.58
CSNK2A1 P68400 1/20 0.58
KMT2A Q03164 7/20 0.57
MEN1 O00255 6/20 0.57
MAPT P10636 4/20 0.57
HTT P42858 4/20 0.57
POLB P06746 3/20 0.57
USP2 O75604 2/20 0.57
RGS12 O14924 2/20 0.57
MAPK1 P28482 1/20 0.57
ATM Q13315 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
TLR9 Q9NR96 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
HDAC1 Q13547 5/20 0.52
HDAC6 Q9UBN7 5/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12377349 0.93 MEN1 (0.63) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL13207573 0.86 KMT2A (0.57) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL10104264 0.86 KMT2A (0.56) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL20080440 0.86 MEN1 (0.54) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL1760735 0.85 MEN1 (0.54) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL13207593 0.84 MEN1 (0.55) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL14397350 0.84 MEN1 (0.52) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL1760808 0.82 MEN1 (0.52) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL1580657 0.81 KMT2A (0.84) DYRK3RPS6KB1EPHA2FLT4CSNK2A1
SCHEMBL1760739 0.81 MEN1 (0.51) DYRK3RPS6KB1EPHA2FLT4CSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963436-B1 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES OREAL (FR) 2018-04-25 EP claimed
US-7988741-B2 Specific naphthalmide-type dyes, dye composition comprising at least one such dye, process using same and uses L'OREAL S.A. (FR) 2011-08-02 US claimed
US-20110113572-A1 SPECIFIC NAPHTHALMIDE-TYPE DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, PROCESS USING SAME AND USES L' OREAL S.A. (FR) 2011-05-19 US claimed
EP-1963436-A2 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES L'Oréal (FR) 2008-09-03 EP claimed
WO-2007110530-A2 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES L'OREAL (FR) 2007-10-04 WO claimed
EP-1963436-B1 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES OREAL (FR) 2018-04-25 EP disclosed
US-7988741-B2 Specific naphthalmide-type dyes, dye composition comprising at least one such dye, process using same and uses L'OREAL S.A. (FR) 2011-08-02 US disclosed
US-7988741-B2 Specific naphthalmide-type dyes, dye composition comprising at least one such dye, process using same and uses L'OREAL S.A. (FR) 2011-08-02 US disclosed
US-20110113572-A1 SPECIFIC NAPHTHALMIDE-TYPE DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, PROCESS USING SAME AND USES L' OREAL S.A. (FR) 2011-05-19 US disclosed
US-20110113572-A1 SPECIFIC NAPHTHALMIDE-TYPE DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, PROCESS USING SAME AND USES L' OREAL S.A. (FR) 2011-05-19 US disclosed
US-20110113572-A1 SPECIFIC NAPHTHALMIDE-TYPE DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, PROCESS USING SAME AND USES L' OREAL S.A. (FR) 2011-05-19 US disclosed
EP-1963436-A2 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES L'Oréal (FR) 2008-09-03 EP disclosed
WO-2007110530-A2 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES L'OREAL (FR) 2007-10-04 WO disclosed
WO-2007110530-A2 SPECIFIC DYES OF NAPHTHALIMIDE TYPE, DYEING COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, METHOD OF IMPLEMENTATION AND USES L'OREAL (FR) 2007-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110113572-A1 SPECIFIC NAPHTHALMIDE-TYPE DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, PROCESS USING SAME AND USES KRT18, NEFM, NDC1 DYRK3 2043/4885RPS6KB1 3830/4885EPHA2 4734/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.