Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | S100A9 | P06702 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608573 | 0.84 | MAPT (0.39) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL19367478 | 0.80 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2ALOX5AP | |
| SCHEMBL17608496 | 0.77 | DYRK1B (0.36) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL14911037 | 0.75 | HDAC3 (0.52) | MAPTNPC1RAB9AMAPK1HDAC3 | |
| SCHEMBL210885 | 0.73 | MKNK1 (0.48) | PIK3CAPIK3CDPIK3CG | |
| SCHEMBL17608426 | 0.72 | MKNK1 (0.35) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL1854838 | 0.71 | CYP1A1 (0.44) | MAPTNPC1RAB9AMAPK1ADORA3 | |
| SCHEMBL19367483 | 0.70 | PRMT5 (0.41) | NPC1RAB9ASMN1; SMN2ALOX5APALDH1A1 | |
| SCHEMBL1558307 | 0.70 | MAPT (0.41) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL17608163 | 0.70 | AURKA (0.38) | MAPTAURKAAURKBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-21 | — | — | US | disclosed |
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-21 | — | — | US | disclosed |
| EP-3194369-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | Verseon Corporation (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044662-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON CORPORATION (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044662-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON CORPORATION (US) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | SERPINE1, PRSS1, SPINT2 | MAPT 2371/4885CASP1 183/4885AURKA 672/4885 |
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | SERPINE1, PRSS1, SPINT2 | MAPT 2371/4885CASP1 183/4885AURKA 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.