Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608640 | 0.88 | MAPT (0.48) | POLBMAPTNTRK1CDK8CCNC | |
| SCHEMBL17608253 | 0.84 | CCNC (0.47) | POLBMAPTCSNK1DNTRK1CDK8 | |
| SCHEMBL17608454 | 0.83 | CCNC (0.48) | POLBMAPTCSNK1DNTRK1CDK8 | |
| SCHEMBL17608387 | 0.78 | CDK8 (0.68) | CSNK1DCDK8CCNCHSP90AA1HSP90AB1 | |
| SCHEMBL17608532 | 0.73 | HSP90AA1 (0.56) | CDK8CCNCHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL17608705 | 0.73 | CDK8 (0.53) | CDK8CCNCHSP90AA1HSP90AB1PARP1 | |
| SCHEMBL17608408 | 0.72 | HSP90AA1 (0.54) | CDK8CCNCHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL12907392 | 0.71 | MAPK1 (0.56) | CSNK1DCDK8CCNCTTKMAPK3 | |
| SCHEMBL1733775 | 0.68 | HSP90AA1 (0.68) | CDK8HSP90AA1HSP90AB1 | |
| SCHEMBL20217228 | 0.66 | MAPK1 (0.77) | CSNK1DTTKMAPK3MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | claimed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |