Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3110983 | 0.89 | PIK3CA (0.44) | PIK3CALMNAMAPTAPLNRMEN1 | |
| SCHEMBL168144 | 0.86 | PIK3CA (0.38) | PIK3CALMNAMAPTPIK3R1MTOR | |
| SCHEMBL169240 | 0.85 | PIK3CA (0.44) | PIK3CALMNAMAPTQPCTALDH1A1 | |
| SCHEMBL116627 | 0.85 | PIK3CA (0.49) | PIK3CALMNAMAPTQPCTALDH1A1 | |
| SCHEMBL166903 | 0.84 | PIK3CA (0.43) | PIK3CALMNAMAPTQPCTALDH1A1 | |
| SCHEMBL168049 | 0.84 | PIK3CA (0.43) | PIK3CALMNAMAPTQPCTALDH1A1 | |
| SCHEMBL114564 | 0.82 | PIK3CA (0.42) | PIK3CALMNAMAPTQPCTPDE2A | |
| SCHEMBL167477 | 0.82 | PIK3CA (0.43) | PIK3CALMNAMAPTPIK3R1MTOR | |
| SCHEMBL167060 | 0.81 | PIK3CA (0.38) | PIK3CALMNAMAPTALDH1A1CACNA1I | |
| SCHEMBL3108787 | 0.81 | PIK3CA (0.41) | PIK3CALMNAMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |