Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 17/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1485015 | 0.87 | MAP3K14 (0.44) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1484994 | 0.86 | MAP3K14 (0.55) | MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL12539208 | 0.84 | MAP3K14 (0.40) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL12539507 | 0.84 | MAP3K14 (0.40) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1485071 | 0.84 | MAP3K14 (0.42) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1485289 | 0.84 | MAP3K14 (0.40) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL12689314 | 0.84 | MAP3K14 (0.43) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1484978 | 0.83 | MAP3K14 (0.43) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL15490518 | 0.82 | MAP3K14 (0.40) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL19594749 | 0.82 | PIK3CA (0.42) | MAP3K14PIK3CDPIK3R1PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2711368-B1 | Benzoxazepin PI3K inhibitor compounds and methods of use | HOFFMANN LA ROCHE (CH) | 2016-03-23 | — | — | EP | disclosed |