Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613807 | 0.90 | PDE9A (0.54) | PDE9APDE1CACHE | |
| SCHEMBL7887087 | 0.86 | PDE9A (0.59) | PDE9APDE1CACHE | |
| SCHEMBL7885849 | 0.85 | PDE9A (0.77) | PDE9APDE1CACHE | |
| SCHEMBL12401254 | 0.80 | PDE9A (0.54) | PDE9APDE1CACHE | |
| SCHEMBL7887934 | 0.80 | PDE9A (0.74) | PDE9APDE1CACHE | |
| SCHEMBL7884937 | 0.79 | PDE9A (0.58) | PDE9APDE1C | |
| SCHEMBL12401183 | 0.78 | PDE9A (0.71) | PDE9APDE1CACHE | |
| SCHEMBL7887928 | 0.78 | PDE9A (0.55) | PDE9APDE1CACHE | |
| SCHEMBL7884510 | 0.77 | PDE9A (0.52) | PDE9APDE1CACHE | |
| SCHEMBL2111034 | 0.77 | PDE9A (0.78) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300478-B1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |