Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176136 | 1.00 | ALOX5AP (0.74) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL5139047 | 0.94 | ALOX5AP (0.68) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL176188 | 0.94 | ALOX5AP (0.68) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL20475074 | 0.93 | ALOX5AP (0.85) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL169989 | 0.93 | ALOX5AP (0.85) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL13447684 | 0.91 | ALOX5AP (0.68) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL13447683 | 0.90 | ALOX5AP (0.73) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL3057370 | 0.90 | ALOX5AP (0.67) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL3054747 | 0.87 | ALOX5AP (0.79) | ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL1193620 | 0.86 | ALOX5AP (0.67) | ALOX5APCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018152405-A1 | REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR | AUTOIMMUNE PHARMA LLC (US) | 2018-08-23 | — | — | WO | disclosed |
| EP-1943219-B8 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | PANMIRA PHARMACEUTICALS LLC (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-1943219-A2 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | Amira Pharmaceuticals, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056021-A2 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |